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Phospho-DAXX(S213) Antibody

Phospho-DAXX(S213) Antibody

ArtNr	ABC-AP3082a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Daxx, DAXX, BING2, DAP6, Death domain-associated protein 6, ETS1-associated protein 1, Fas death domain-associated protein, EAP1, hDaxx
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Primary Accession	Q9UER7
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	DAXX is proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. DAXX seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. This protein down-regulates basal and activated transcription, and it also seems to act as a transcriptional co-repressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. DAXX modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.
Bio References	Cantrell, S.R., et al., J. Virol. 79(12):7792-7802 (2005). Greger, J.G., et al., J. Virol. 79(8):4610-4618 (2005). Chang, C.C., et al., J. Biol. Chem. 280(11):10164-10173 (2005). Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004). Gostissa, M., et al., J. Biol. Chem. 279(46):48013-48023 (2004).
Clonality	Polyclonal
Clone/Animal Names	RB6929
Gene ID	1616
Gene Name	DAXX
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	The anti-Phospho-DAXX-S213 Pab (Cat. #AP73082a) is used in Western blot to detect Phospho-DAXX-S213 in mouse thymus tissue lysate
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Other Accession	Q8VIB2; O35613
Predicted	M, Rat
Isotype	Rabbit Ig
Calculated MW	81373
Antigen Source	HUMAN
Target/Specificity	This DAXX Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S213 of human DAXX.
NCBI Accession	NP_001135441.1; NP_001241646.1; NP_001341.1

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Menge: 400 ul

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