LECT1 Antibody (C-term)

Synthetic Peptide

LECT1 a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This protein is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development.

Polyclonal

11061

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of anti-LECT1 Antibody (C-term) (Cat.#AP2729b) in NCI-H460 cell line lysates (35ug/lane).LECT1(arrow) was detected using the purified Pab.

1:1000

WB

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with LECT1 antibody (C-term) (Cat.#Ap2729b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

1:10~50

B, M, Rb, Rat

37102

HUMAN

NP_001011705.1; NP_008946.1