SEMA4D Antibody (C-term)

Q92854

Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.

polyclonal

10507

Purified Rabbit Polyclonal Antibody (Pab)

All lanes : Anti-SEMA4D Antibody (C-term) at 1:2000 dilution
Lane 1: Jurkat whole cell lysates
Lane 2: HL-60 whole cell lysates

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

Predicted band size : 96 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

1:2000

96150

This SEMA4D antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 793-832 amino acids from the C-terminal region of human SEMA4D.