Mouse Mertk Antibody (C-term)

Q60805

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

polyclonal

17289

Purified Rabbit Polyclonal Antibody (Pab)

All lanes : Anti-Mertk Antibody (C-term) at 1:2000 dilution
Lane 1: mouse kidney lysates
Lane 2: mouse liver lysates
Lane 3: NIH/3T3 whole cell lysates
Lane 4: rat kidney lysates
Lane 5: rat liver lysates

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

Predicted band size : 110 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

1:2000

WB

Rabbit Ig

HUMAN