ArtNr |
ABC-AP2061A-ev |
Hersteller |
Abcepta
|
Menge |
80 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
GDF11, BMP11, Growth/differentiation factor 11, Bone morphogenetic protein 11, GDF-11, BMP-11 |
Lieferbar |
|
Primary Accession |
O95390 |
Antigen Type |
Synthetic Peptide |
Application |
IHC-P, WB |
Bio Background |
GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. |
Bio References |
Lee, S.J., et al., Curr. Opin. Genet. Dev. 9(5):604-607 (1999).McPherron, A.C., et al., Nat. Genet. 22(3):260-264 (1999).Gamer, L.W., et al., Dev. Biol. 208(1):222-232 (1999).Hillier, L.D., et al., Genome Res. 6(9):807-828 (1996). |
Clonality |
Polyclonal |
Clone/Animal Names |
RB01875-01876 |
Gene ID |
10220 |
Gene Name |
GDF11 |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H, M |
Legend image 1 |
All lanes : Anti-hGDF11-R47 at 1:2000 dilutionLane 1: human heart lysateLane 2: K562 whole cell lysateLane 3: mouse kidney lysateLane 4: 293 whole cell lysateLane 5: Hela whole cell lysateLane 5: mouse brain lysateLysates/proteins at 20 µg per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 45 kDaBlocking/Dilution buffer: 5% NFDM/TBST. |
Type image 1 |
WB |
Dilution image 1 |
1:2000 |
Legend image 2 |
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with GDF11 antibody (N-term) (Cat.#AP2061a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Type image 2 |
IHC-P |
Dilution image 2 |
1:10~50 |
Legend image 3 |
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with GDF11 antibody (N-term) (Cat.#AP2061a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Type image 3 |
IHC-P |
Dilution image 3 |
1:10~50 |
Isotype |
Rabbit Ig |
Calculated MW |
45091 |
Antigen Region |
32-61 |
Antigen Source |
HUMAN |
Target/Specificity |
This GDF11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human GDF11. |
NCBI Accession |
NP_005802.1 |
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