ArtNr |
ABC-AP20081a-ev |
Hersteller |
Abcepta
|
Menge |
80 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
RRM1, RR1, Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit |
Lieferbar |
|
Primary Accession |
P23921 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
This gene encodes one of two non-identical subunits thatconstitute ribonucleoside-diphosphate reductase, an enzymeessential for the production of deoxyribonucleotides prior to DNAsynthesis in S phase of dividing cells. It is one of several geneslocated in the imprinted gene domain of 11p15.5, an importanttumor-suppressor gene region. Alterations in this region have beenassociated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, andbreast cancer. This gene may play a role in malignancies anddisease that involve this region. |
Bio References |
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Vinolas, N., et al. Lung Cancer (2010) In press :Niida, H., et al. Genes Dev. 24(4):333-338(2010)Dong, S., et al. J Hematol Oncol 3, 10 (2010) : |
Clonality |
Polyclonal |
Clone/Animal Names |
RB42407 |
Gene ID |
6240 |
Gene Name |
RRM1 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
RRM1 Antibody (N-term) (Cat. #AP20081a) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RRM1 antibody detected the RRM1 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Other Accession |
P07742; NP_001024.1 |
Predicted |
M |
Isotype |
Rabbit Ig |
Calculated MW |
90070 |
Antigen Region |
71-100 |
Antigen Source |
HUMAN |
Target/Specificity |
This RRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human RRM1. |
NCBI Accession |
NP_001024.1 |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.