Bio Background |
This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. |
Bio References |
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010) Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010) Vinolas, N., et al. Lung Cancer (2010) In press : Niida, H., et al. Genes Dev. 24(4):333-338(2010) Dong, S., et al. J Hematol Oncol 3, 10 (2010) : |