ArtNr |
ABC-AP2004D |
Hersteller |
Abcepta
|
Menge |
200 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Applikationen |
WB, IHC-P |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
BMPR1A, Bone morphogenetic protein receptor type-1A, Activin receptor-like kinase 3, Serine/threonine-protein kinase receptor R5, ACVRLK3, ALK3, CD292, SKR5, ALK-3, BMPR-1A, BMP type-1A receptor |
Lieferbar |
|
Primary Accession |
P36894 |
Antigen Type |
Synthetic Peptide |
Application |
IHC-P, WB |
Bio Background |
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. |
Bio References |
Zhou, X.-P., et al., Am. J. Hum. Genet. 69(4):704-711 (2001).Howe, J.R., et al., Nat. Genet. 28(2):184-187 (2001).ten Dijke, P., et al., Oncogene 8(10):2879-2887 (1993). |
Clonality |
Polyclonal |
Clone/Animal Names |
RB05263 |
Gene ID |
657 |
Gene Name |
BMPR1A |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
Anti-BMPR1A Antibody (C180) at 1:2000 dilution + Hela whole cell lysateLysates/proteins at 20 µg per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 60 kDaBlocking/Dilution buffer: 5% NFDM/TBST. |
Type image 1 |
WB |
Dilution image 1 |
1:2000 |
Legend image 2 |
Western blot analysis of lysates from 293, mouse NIH/3T3 cell line (from left to right), using BMPR1A Antibody (C180) (Cat. #AP2004d). AP2004d was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane. |
Type image 2 |
WB |
Dilution image 2 |
1:1000 |
Legend image 3 |
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
Type image 3 |
IHC-P |
Dilution image 3 |
1:50~100 |
Isotype |
Rabbit Ig |
Calculated MW |
60198 |
Antigen Region |
166-195 |
Antigen Source |
HUMAN |
Target/Specificity |
This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-195 amino acids from the Central region of human BMPR1A. |
NCBI Accession |
NP_004320.2 |
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