Bio Background |
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. |
Bio References |
Borthakur, A., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (4), G928-G934 (2010) : Singh, N., et al. J. Biol. Chem. 285(36):27601-27608(2010) Becker, H.M., et al. Am. J. Physiol. Renal Physiol. 299 (1), F141-F154 (2010) : Miyauchi, S., et al. Biochim. Biophys. Acta 1798(6):1164-1171(2010) Cresci, G.A., et al. J. Gastrointest. Surg. 14(3):449-461(2010) |