Alias |
YEATS domain-containing protein 4, Glioma-amplified sequence 41, Gas41, NuMA-binding protein 1, NuBI-1, NuBI1, YEATS4, GAS41 |
Bio Background |
NuBI-1 is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. The gene for this protein has been shown to be amplified in tumors. |
Bio References |
Zimmermann, K., et al., J. Biol. Chem. 277(21):18626-18631 (2002). Debernardi, S., et al., Blood 99(1):275-281 (2002). Harborth, J., et al., J. Biol. Chem. 275(41):31979-31985 (2000). Fischer, U., et al., Hum. Mol. Genet. 6(11):1817-1822 (1997). Gracia, E., et al., Hum. Mol. Genet. 5(5):595-600 (1996). |