PSG4 Antibody (N-term)

NP_002771.2

The human pregnancy-specific glycoproteins (PSGs) are a
family of proteins that are synthesized in large amounts by
placental trophoblasts and released into the maternal circulation
during pregnancy. Molecular cloning and analysis of several PSG
genes has indicated that the PSGs form a subgroup of the
carcinoembryonic antigen (CEA) gene family, which belongs to the
immunoglobulin superfamily of genes. Members of the CEA family
consist of a single N domain, with structural similarity to the
immunoglobulin variable domains, followed by a variable number of
immunoglobulin constant-like A and/or B domains. Most PSGs have an
arg-gly-asp (RGD) motif, which has been shown to function as an
adhesion recognition signal for several integrins, in the
N-terminal domain (summary by Teglund et al., 1994 [PubMed
7851896]). For additional general information about the PSG gene
family, see PSG1 (MIM 176390).

5672

H

73-100

This PSG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-100 amino acids from the N-terminal region of human PSG4.