FZR1 Antibody (N-term)

Synthetic Peptide

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Polyclonal

51343

Affinity Purified Rabbit Polyclonal Antibody (Pab)

FZR1 Antibody (N-term) (Cat. #AP19009a) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the FZR1 antibody detected the FZR1 protein (arrow).

1:1000

M

55179

HUMAN

NP_001129669.1; NP_001129670.1; NP_057347.2