PCDHGB4 Antibody (Center)

Synthetic Peptide

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes.

Polyclonal

8641

Affinity Purified Rabbit Polyclonal Antibody (Pab)

PCDHGB4 Antibody (Center)(Cat. #AP18848c) western blot analysis in Uterus tissue lysates (35ug/lane).This demonstrates the PCDHGB4 antibody detected the PCDHGB4 protein (arrow).

1:1000

Rabbit Ig

353-379

This PCDHGB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-379 amino acids from the Central region of human PCDHGB4.