ArtNr |
ABC-AP18214C-ev |
Hersteller |
Abcepta
|
Menge |
80 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
PCDHA1, Protocadherin alpha-1, PCDH-alpha-1 |
Lieferbar |
|
Primary Accession |
Q9Y5I3 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
This gene is a member of the protocadherin alpha genecluster, one of three related gene clusters tandemly linked onchromosome five that demonstrate an unusual genomic organizationsimilar to that of B-cell and T-cell receptor gene clusters. Thealpha gene cluster is composed of 15 cadherin superfamily genesrelated to the mouse CNR genes and consists of 13 highly similarand 2 more distantly related coding sequences. The tandem array of15 N-terminal exons, or variable exons, are followed by downstreamC-terminal exons, or constant exons, which are shared by all genesin the cluster. The large, uninterrupted N-terminal exons eachencode six cadherin ectodomains while the C-terminal exons encodethe cytoplasmic domain. These neural cadherin-like cell adhesionproteins are integral plasma membrane proteins that most likelyplay a critical role in the establishment and function of specificcell-cell connections in the brain. Alternative splicing has beenobserved and additional variants have been suggested but theirfull-length nature has yet to be determined. |
Bio References |
Lachman, H.M., et al. Psychiatr. Genet. 18(3):110-115(2008)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Wu, Q., et al. Genome Res. 11(3):389-404(2001)Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB32960 |
Gene ID |
56147 |
Gene Name |
PCDHA1 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
PCDHA1 Antibody (Center) (Cat. #AP18214c) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PCDHA1 antibody detected the PCDHA1 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Other Accession |
NP_061723.1 |
Isotype |
Rabbit Ig |
Calculated MW |
102952 |
Antigen Region |
288-316 |
Antigen Source |
HUMAN |
Target/Specificity |
This PCDHA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-316 amino acids from the Central region of human PCDHA1. |
NCBI Accession |
NP_061723.1; NP_113598.1; NP_113599.1 |
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