RGL4 Antibody (N-term)

Synthetic Peptide

Ral GDS (Ral guanine nucleotide dissociation stimulator) is a guanine nucleotide exchange factor (GEF) that activates Ral and is implicated in oncogenic Ras-induced cell transformation. RGL4 (ral guanine nucleotide dissociation stimulator-like 4), also known as Rgr, is a 473 amino acid protein that localizes to the cytoplasmic vesicle of cells. Belonging to the GEF family of proteins, RGL4 induces phosphorylation of ERKs, p38 and JNK kinases, and it increases the levels of GTP bound forms of Ral and Ras. Ras activation is crucial for the transforming activity of RGL4. Due to its similarity to Ral GDS, RGL4 may be implicated in carcinogenesis.

Polyclonal

266747

Affinity Purified Rabbit Polyclonal Antibody (Pab)

RGL4 Antibody (N-term) (Cat. #AP17597a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the RGL4 antibody detected the RGL4 protein (arrow).

1:1000

Rabbit Ig

98-125

This RGL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-125 amino acids from the N-terminal region of human RGL4.