DUSP6 Antibody (N-term)

Q2KJ36; NP_073143.2; NP_001937.2

The protein encoded by this gene is a member of the dual
specificity protein phosphatase subfamily. These phosphatases
inactivate their target kinases by dephosphorylating both the
phosphoserine/threonine and phosphotyrosine residues. They
negatively regulate members of the mitogen-activated protein (MAP)
kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated
with cellular proliferation and differentiation. Different members
of the family of dual specificity phosphatases show distinct
substrate specificities for various MAP kinases, different tissue
distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This
gene product inactivates ERK2, is expressed in a variety of tissues
with the highest levels in heart and pancreas, and unlike most
other members of this family, is localized in the cytoplasm. Two
transcript variants encoding different isoforms have been found for
this gene.

1848

H, M

42320

HUMAN

NP_001937.2; NP_073143.2