ZP3 Antibody (C-term)

Synthetic Peptide

The zona pellucida is an extracellular matrix that
surrounds the oocyte and early embryo. It is composed primarily of
three or four glycoproteins with various functions during
fertilization and preimplantation development. The protein encoded
by this gene is a structural component of the zona pellucida and
functions in primary binding and induction of the sperm acrosome
reaction. The nascent protein contains a N-terminal signal peptide
sequence, a conserved ZP domain, a C-terminal consensus furin
cleavage site, and a transmembrane domain. It is hypothesized that
furin cleavage results in release of the mature protein from the
plasma membrane for subsequent incorporation into the zona
pellucida matrix. However, the requirement for furin cleavage in
this process remains controversial based on mouse studies. A
variation in the last exon of this gene has previously served as
the basis for an additional ZP3 locus; however, sequence and
literature review reveals that there is only one full-length ZP3
locus in the human genome. Another locus encoding a bipartite
transcript designated POMZP3 contains a duplication of the last
four exons of ZP3, including the above described variation, and
maps closely to this gene.

Polyclonal

7784

Affinity Purified Rabbit Polyclonal Antibody (Pab)

ZP3 Antibody (C-term) (Cat. #AP17235b) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the ZP3 antibody detected the ZP3 protein (arrow).

1:1000

Rabbit Ig

353-380

This ZP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-380 amino acids from the C-terminal region of human ZP3.