HNRNPH3 Antibody (Center)

NP_036339.1; NP_067676.2

This gene belongs to the subfamily of ubiquitously
expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
hnRNPs are RNA binding proteins and they complex with heterogeneous
nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs
in the nucleus and appear to influence pre-mRNA processing and
other aspects of mRNA metabolism and transport. While all of the
hnRNPs are present in the nucleus, some seem to shuttle between the
nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic
acid binding properties. The protein encoded by this gene has two
repeats of quasi-RRM domains that bind to RNAs. It is localized in
nuclear bodies of the nucleus. This protein is involved in the
splicing process and it also participates in early heat
shock-induced splicing arrest by transiently leaving the hnRNP
complexes. Several alternatively spliced transcript variants have
been noted for this gene, however, not all are fully characterized.

3189

H

90-117

This HNRNPH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-117 amino acids from the Central region of human HNRNPH3.