Bio Background |
Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 [PubMed 11724789]). |
Bio References |
Gao, X., et al. J. Cell. Biochem. 110(1):162-170(2010) Carascossa, S., et al. Genes Dev. 24(7):708-719(2010) Kim, Y.R., et al. BMC Cancer 10, 197 (2010) : Ito, T., et al. BMC Dev. Biol. 9, 47 (2009) : Haiman, C.A., et al. BMC Cancer 9, 43 (2009) : |