SPG20 Antibody (C-term)

Synthetic Peptide

SPG20 is a protein containing a MIT (Microtubule
Interacting and Trafficking molecule) domain, and is implicated in
regulating endosomal trafficking and mitochondria function. The
protein localizes to mitochondria and partially co-localizes with
microtubules. Stimulation with epidermal growth factor (EGF)
results in protein translocation to the plasma membrane, and the
protein functions in the degradation and intracellular trafficking
of EGF receptor. Multiple alternatively spliced variants, encoding
the same protein, have been identified. Mutations associated with
this gene cause autosomal recessive spastic paraplegia 20 (Troyer
syndrome).

Polyclonal

23111

Affinity Purified Rabbit Polyclonal Antibody (Pab)

SPG20 Antibody (C-term) (Cat. #AP16276b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SPG20 antibody detected the SPG20 protein (arrow).

1:1000

B, M

72833

HUMAN

NP_001135766.1; NP_001135767.1; NP_001135768.1; NP_055902.1