ArtNr |
ABC-AP16014a |
Hersteller |
Abcepta
|
Menge |
400 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
FOLR2, Folate receptor beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FR-beta |
Lieferbar |
|
Primary Accession |
P14207 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
The protein encoded by this gene is a member of the folatereceptor (FOLR) family, and these genes exist in a cluster onchromosome 11. Members of this gene family have a high affinity forfolic acid and for several reduced folic acid derivatives, and theymediate delivery of 5-methyltetrahydrofolate to the interior ofcells. This protein has a 68% and 79% sequence homology with theFOLR1 and FOLR3 proteins, respectively. Although this protein wasoriginally thought to be specific to placenta, it can also exist inother tissues, and it may play a role in the transport ofmethotrexate in synovial macrophages in rheumatoid arthritispatients. Multiple transcript variants that encode the same proteinhave been found for this gene. |
Bio References |
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)O'Byrne, M.R., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(8):689-694(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Puig-Kroger, A., et al. Cancer Res. 69(24):9395-9403(2009) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB31620 |
Gene ID |
2350 |
Gene Name |
FOLR2 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
FOLR2 Antibody (N-term) (Cat. #AP16014a) western blot analysis in MDA-MB453, NCI-H460 cell line lysates (35ug/lane).This demonstrates the FOLR2 antibody detected the FOLR2 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Other Accession |
Q05685; NP_001107008.1; NP_000794.3; NP_001107007.1 |
Predicted |
M |
Isotype |
Rabbit Ig |
Calculated MW |
29280 |
Antigen Region |
17-44 |
Antigen Source |
HUMAN |
Target/Specificity |
This FOLR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-44 amino acids from the N-terminal region of human FOLR2. |
NCBI Accession |
NP_000794.3; NP_001107006.1; NP_001107007.1; NP_001107008.1 |
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