Alias |
CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7 |
Bio Background |
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. |
Bio References |
Arimoto-Miyamoto, K., et al. Immunology 130(1):137-149(2010) Shaw, J., et al. Blood 115(15):3051-3057(2010) Yu, S.E., et al. Mol. Cells 29(2):217-221(2010) Kozlowska, A., et al. J. Rheumatol. 37(1):53-59(2010) Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) : |