COL1A1 Antibody (C-term)

Synthetic Peptide

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish].

Polyclonal

1277

Affinity Purified Rabbit Polyclonal Antibody (Pab)

COL1A1 Antibody (C-term) (Cat. #AP14490b) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the COL1A1 antibody detected the COL1A1 protein (arrow).

1:1000

IHC-P

P02454; P11087; P02457; P02453; NP_000079.2

Rabbit Ig

1077-1106

This COL1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1077-1106 amino acids from the C-terminal region of human COL1A1.