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Mouse Pak4 Antibody (Center)

Mouse Pak4 Antibody (Center)

ArtNr	ABC-AP14453C
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, FC
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Pak4, Kiaa1142, Serine/threonine-protein kinase PAK 4, p21-activated kinase 4, PAK-4
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Primary Accession	Q8BTW9
Antigen Type	Synthetic Peptide
Application	WB, FC
Bio Background	Pak4 activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2 (By similarity).
Bio References	Liu, Y., et al. Oncogene 29(44):5883-5894(2010) Tian, Y., et al. Mech. Dev. 126 (8-9), 710-720 (2009) : Ha, U.H., et al. J. Biol. Chem. 283(45):30624-30631(2008) Liu, Y., et al. Mol. Cancer Res. 6(7):1215-1224(2008) Danzer, K.M., et al. J. Neurochem. 103(6):2401-2407(2007)
Clonality	Polyclonal
Clone/Animal Names	RB34853
Gene ID	70584
Gene Name	Pak4
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	Mouse Pak4 Antibody (Center) (Cat. #AP14453c) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the Pak4 antibody detected the Pak4 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Mouse Pak4 Antibody (Center) (Cat. #AP14453c) western blot analysis in Neuro-2a cell line lysates (35ug/lane).This demonstrates the Pak4 antibody detected the Pak4 protein (arrow).
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	Mouse Pak4 Antibody (Center) (Cat. #AP14453c) flow cytometric analysis of Neuro-2a cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Other Accession	O96013; NP_081746.1
Isotype	Rabbit Ig
Calculated MW	64623
Antigen Region	187-216
Antigen Source	MOUSE
Target/Specificity	This Mouse Pak4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of mouse Pak4.
NCBI Accession	NP_081746.1

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ABC-AP14453C-datasheet.pdf

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Menge: 400 ul

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