ArtNr |
ABC-AP14453C |
Hersteller |
Abcepta
|
Menge |
400 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB, FC |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
Pak4, Kiaa1142, Serine/threonine-protein kinase PAK 4, p21-activated kinase 4, PAK-4 |
Lieferbar |
|
Primary Accession |
Q8BTW9 |
Antigen Type |
Synthetic Peptide |
Application |
WB, FC |
Bio Background |
Pak4 activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2 (By similarity). |
Bio References |
Liu, Y., et al. Oncogene 29(44):5883-5894(2010)Tian, Y., et al. Mech. Dev. 126 (8-9), 710-720 (2009) :Ha, U.H., et al. J. Biol. Chem. 283(45):30624-30631(2008)Liu, Y., et al. Mol. Cancer Res. 6(7):1215-1224(2008)Danzer, K.M., et al. J. Neurochem. 103(6):2401-2407(2007) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB34853 |
Gene ID |
70584 |
Gene Name |
Pak4 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H, M |
Legend image 1 |
Mouse Pak4 Antibody (Center) (Cat. #AP14453c) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the Pak4 antibody detected the Pak4 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
Mouse Pak4 Antibody (Center) (Cat. #AP14453c) western blot analysis in Neuro-2a cell line lysates (35ug/lane).This demonstrates the Pak4 antibody detected the Pak4 protein (arrow). |
Type image 2 |
WB |
Dilution image 2 |
1:1000 |
Legend image 3 |
Mouse Pak4 Antibody (Center) (Cat. #AP14453c) flow cytometric analysis of Neuro-2a cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis. |
Type image 3 |
FC |
Dilution image 3 |
1:10~50 |
Other Accession |
O96013; NP_081746.1 |
Isotype |
Rabbit Ig |
Calculated MW |
64623 |
Antigen Region |
187-216 |
Antigen Source |
MOUSE |
Target/Specificity |
This Mouse Pak4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of mouse Pak4. |
NCBI Accession |
NP_081746.1 |
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