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TAU (MAPT) Antibody (S720)

TAU (MAPT) Antibody (S720)

ArtNr	ABC-AP1425c-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MAPT, TAU, MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau
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Primary Accession	P10636
Antigen Type	Synthetic Peptide
Application	WB, IHC-P, IHC
Bio Background	MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Bio References	McCulloch, C.C., Hum. Genet. 123 (3), 257-265 (2008) Mateo, I., Dement Geriatr Cogn Disord 25 (4), 317-320 (2008) Beck, J., Brain 131 (PT 3), 706-720 (2008)
Clonality	Polyclonal
Clone/Animal Names	RB11005
Gene ID	4137
Gene Name	MAPT (HGNC:6893)
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, Cynomolgus Monkey
Legend image 1	MAPT Antibody (pS720) (Cat.# AP1425c) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the MAPT antibody detected the MAPT protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	AP1425c staining TAU in Monkey brain tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
Type image 2	IHC
Dilution image 2	1:25
Legend image 3	Formalin-fixed and paraffin-embedded human brain tissue reacted with MAPT Antibody (S720) (Cat.#AP1425c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 3	IHC-P
Dilution image 3	1:10~50
Other Accession	P19332; P10637; P29172
Predicted	B, M, Rat
Isotype	Rabbit Ig
Calculated MW	78928
Antigen Region	699-728
Antigen Source	HUMAN
Target/Specificity	This TAU(MAPT) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 699-728 amino acids from human TAU(MAPT).
NCBI Accession	NP_001116538.2; NP_001116539.1; NP_001190181.1; NP_005901.2; NP_058518.1; NP_058519.3; NP_058525.1

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