ArtNr |
ABC-AP1425c-ev |
Hersteller |
Abcepta
|
Menge |
80 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB, IHC, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
MAPT, TAU, MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau |
Lieferbar |
|
Primary Accession |
P10636 |
Antigen Type |
Synthetic Peptide |
Application |
WB, IHC-P, IHC |
Bio Background |
MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. |
Bio References |
McCulloch, C.C., Hum. Genet. 123 (3), 257-265 (2008)Mateo, I., Dement Geriatr Cogn Disord 25 (4), 317-320 (2008)Beck, J., Brain 131 (PT 3), 706-720 (2008) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB11005 |
Gene ID |
4137 |
Gene Name |
|
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H, Cynomolgus Monkey |
Legend image 1 |
MAPT Antibody (pS720) (Cat.# AP1425c) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the MAPT antibody detected the MAPT protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
AP1425c staining TAU in Monkey brain tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody. |
Type image 2 |
IHC |
Dilution image 2 |
1:25 |
Legend image 3 |
Formalin-fixed and paraffin-embedded human brain tissue reacted with MAPT Antibody (S720) (Cat.#AP1425c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Type image 3 |
IHC-P |
Dilution image 3 |
1:10~50 |
Other Accession |
P19332; P10637; P29172 |
Predicted |
B, M, Rat |
Isotype |
Rabbit Ig |
Calculated MW |
78928 |
Antigen Region |
699-728 |
Antigen Source |
HUMAN |
Target/Specificity |
This TAU(MAPT) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 699-728 amino acids from human TAU(MAPT). |
NCBI Accession |
NP_001116538.2; NP_001116539.1; NP_001190181.1; NP_005901.2; NP_058518.1; NP_058519.3; NP_058525.1 |
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