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NOX4 Antibody (N-term)

NOX4 Antibody (N-term)

ArtNr	ABC-AP14025A-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	NOX4, RENOX, NADPH oxidase 4, Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, Renal NAD(P)H-oxidase, KOX-1, 163-
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Primary Accession	Q9NPH5
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
Bio References	Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Salmeen, A., et al. Oncogene 29(31):4473-4484(2010) Wu, R.F., et al. Mol. Cell. Biol. 30(14):3553-3568(2010) Diebold, I., et al. Mol. Biol. Cell 21(12):2087-2096(2010) Manea, A., et al. Biochem. Biophys. Res. Commun. 396(4):901-907(2010)
Clonality	Polyclonal
Clone/Animal Names	RB34043
Gene ID	50507
Gene Name	NOX4
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	All lanes : Anti-NOX4 Antibody (N-term) at 1:2000 dilution Lane 1: Human kidney lysate Lane 2: SH-SY5Y whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 67 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1	WB
Dilution image 1	1:2000
Legend image 2	All lanes : Anti-NOX4 Antibody (N-term) at 1:2000 dilution Lane 1: Human kidney lysate Lane 2: HUVEC whole cell lysate Lane 3: U-251 MG whole cell lysate Lane 4: U-87 MG whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 67 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 2	WB
Dilution image 2	1:2000
Legend image 3	NOX4 Antibody (N-term) (AP14025a)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NOX4 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 3	IHC-P
Dilution image 3	1:10~50
Other Accession	NP_001137308.1; NP_058627.1
Isotype	Rabbit Ig
Calculated MW	66932
Antigen Region	124-153
Antigen Source	HUMAN
Target/Specificity	This NOX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-153 amino acids from the N-terminal region of human NOX4.
NCBI Accession	NP_001137308.1; NP_058627.1

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Menge: 80 ul

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