ArtNr |
ABC-AP14025A-ev |
Hersteller |
Abcepta
|
Menge |
80 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
NOX4, RENOX, NADPH oxidase 4, Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, Renal NAD(P)H-oxidase, KOX-1, 163- |
Lieferbar |
|
Primary Accession |
Q9NPH5 |
Antigen Type |
Synthetic Peptide |
Application |
IHC-P, WB |
Bio Background |
This gene encodes a member of the NOX-family of enzymesthat functions as the catalytic subunit the NADPH oxidase complex.The encoded protein is localized to non-phagocytic cells where itacts as an oxygen sensor and catalyzes the reduction of molecularoxygen to various reactive oxygen species (ROS). The ROS generatedby this protein have been implicated in numerous biologicalfunctions including signal transduction, cell differentiation andtumor cell growth. A pseudogene has been identified on the otherarm of chromosome 11. Alternative splicing results in multipletranscript variants. |
Bio References |
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Salmeen, A., et al. Oncogene 29(31):4473-4484(2010)Wu, R.F., et al. Mol. Cell. Biol. 30(14):3553-3568(2010)Diebold, I., et al. Mol. Biol. Cell 21(12):2087-2096(2010)Manea, A., et al. Biochem. Biophys. Res. Commun. 396(4):901-907(2010) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB34043 |
Gene ID |
50507 |
Gene Name |
NOX4 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
All lanes : Anti-NOX4 Antibody (N-term) at 1:2000 dilutionLane 1: Human kidney lysateLane 2: SH-SY5Y whole cell lysateLysates/proteins at 20 µg per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 67 kDaBlocking/Dilution buffer: 5% NFDM/TBST. |
Type image 1 |
WB |
Dilution image 1 |
1:2000 |
Legend image 2 |
All lanes : Anti-NOX4 Antibody (N-term) at 1:2000 dilutionLane 1: Human kidney lysateLane 2: HUVEC whole cell lysateLane 3: U-251 MG whole cell lysateLane 4: U-87 MG whole cell lysateLysates/proteins at 20 µg per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 67 kDaBlocking/Dilution buffer: 5% NFDM/TBST. |
Type image 2 |
WB |
Dilution image 2 |
1:2000 |
Legend image 3 |
NOX4 Antibody (N-term) (AP14025a)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NOX4 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
Type image 3 |
IHC-P |
Dilution image 3 |
1:10~50 |
Other Accession |
NP_001137308.1; NP_058627.1 |
Isotype |
Rabbit Ig |
Calculated MW |
66932 |
Antigen Region |
124-153 |
Antigen Source |
HUMAN |
Target/Specificity |
This NOX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-153 amino acids from the N-terminal region of human NOX4. |
NCBI Accession |
NP_001137308.1; NP_058627.1 |
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