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TLR8 Antibody (Center)

TLR8 Antibody (Center)

ArtNr	ABC-AP14012C
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TLR8, Toll-like receptor 8, CD288
Lieferbar
Primary Accession	Q9NR97
Antigen Type	Synthetic Peptide
Application	WB, IHC-P
Bio Background	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
Bio References	Zannetti, C., et al. J. Biol. Chem. 285(45):34773-34780(2010) Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Cros, J., et al. Immunity 33(3):375-386(2010) Enevold, C., et al. Mult. Scler. 16(8):942-949(2010)
Clonality	Polyclonal
Clone/Animal Names	RB33953
Gene ID	51311
Gene Name	TLR8 (HGNC:15632)
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	TLR8 Antibody (Center) (Cat. #AP14012c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TLR8 antibody detected the TLR8 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	TLR8 Antibody (Center) (AP14012c)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TLR8 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	NP_619542.1
Isotype	Rabbit Ig
Calculated MW	119828
Antigen Region	434-463
Antigen Source	HUMAN
Target/Specificity	This TLR8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 434-463 amino acids from the Central region of human TLR8.
NCBI Accession	NP_619542.1

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ABC-AP14012C-datasheet.pdf

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