Bio Background |
Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B. |
Bio References |
Kajino-Sakamoto, R., et al. J. Immunol. 185(8):4729-4737(2010) Wu, Z.H., et al. Mol. Cell 40(1):75-86(2010) Scholz, R., et al. J. Biol. Chem. 285(33):25753-25766(2010) Greenblatt, M.B., et al. J. Clin. Invest. 120(7):2457-2473(2010) Bettermann, K., et al. Cancer Cell 17(5):481-496(2010) |