Bio Background |
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq]. |
Bio References |
Kim, S.H., et al. J. Biol. Chem. 285(44):34097-34105(2010) Geser, F., et al. Arch. Neurol. 67(10):1238-1250(2010) Mackenzie, I.R., et al. Lancet Neurol 9(10):995-1007(2010) Shan, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16325-16330(2010) McKee, A.C., et al. J. Neuropathol. Exp. Neurol. 69(9):918-929(2010) |