STAT2 Antibody (N-term)

O02799; NP_005410.1; NP_938146.1

The protein encoded by this gene is a member of the STAT
protein family. In response to cytokines and growth factors, STAT
family members are phosphorylated by the receptor associated
kinases, and then form homo- or heterodimers that translocate to
the cell nucleus where they act as transcription activators. In
response to interferon (IFN), this protein forms a complex with
STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in
which this protein acts as a transactivator, but lacks the ability
to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP)
has been shown to interact specifically with this protein, which is
thought to be involved in the process of blocking IFN-alpha
response by adenovirus. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].

6773

H

97916

HUMAN

NP_005410.1; NP_938146.1