ArtNr |
ABC-AP13544a-ev |
Hersteller |
Abcepta
|
Menge |
80 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
SMC1, SMC1A, DXS423E, KIAA0178, SMC1L1, Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb18, SB18 |
Lieferbar |
|
Primary Accession |
Q14683 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
Proper cohesion of sister chromatids is a prerequisite forthe correct segregation of chromosomes during cell division. Thecohesin multiprotein complex is required for sister chromatidcohesion. This complex is composed partly of two structuralmaintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2or the protein encoded by this gene. Most of the cohesin complexesdissociate from the chromosomes before mitosis, although thosecomplexes at the kinetochore remain. Therefore, the encoded proteinis thought to be an important part of functional kinetochores. Inaddition, this protein interacts with BRCA1 and is phosphorylatedby ATM, indicating a potential role for this protein in DNA repair.This gene, which belongs to the SMC gene family, is located in anarea of the X-chromosome that escapes X inactivation. [provided byRefSeq]. |
Bio References |
Limongelli, G., et al. Am. J. Med. Genet. A 152A (8), 2127-2129 (2010) :Homme, C., et al. Oncol. Rep. 24(1):47-56(2010)Pie, J., et al. Am. J. Med. Genet. A 152A (4), 924-929 (2010) :Wong, R.W. Cell Cycle 9(1):198-200(2010)Liu, J., et al. Hum. Mutat. 30(11):1535-1542(2009) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB33672 |
Gene ID |
8243 |
Gene Name |
SMC1A |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
SMC1A Antibody (N-term) (Cat. #AP13544a) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SMC1A antibody detected the SMC1A protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Other Accession |
Q9CU62; O97593; NP_006297.2 |
Predicted |
B, M |
Isotype |
Rabbit Ig |
Calculated MW |
143233 |
Antigen Region |
307-336 |
Antigen Source |
HUMAN |
Target/Specificity |
This SMC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the N-terminal region of human SMC1A. |
NCBI Accession |
NP_006297.2 |
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