Bio Background |
The protein encoded by this gene contains a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Bio References |
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Koike, A., et al. Cancer Res. 70(17):6746-6756(2010) Lilley, C.E., et al. EMBO J. 29(5):943-955(2010) Noon, A.T., et al. Nat. Cell Biol. 12(2):177-184(2010) Ramachandran, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(2):809-814(2010) |