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ERO1L Antibody (C-term)

ERO1L Antibody (C-term)

ArtNr	ABC-AP13305b-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ERO1L, ERO1-like protein alpha, Endoplasmic oxidoreductin-1-like protein, Oxidoreductin-1-L-alpha, ERO1-L, ERO1-L-alpha, 184-
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Primary Accession	Q96HE7
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. Required for the folding of immunoglobulin proteins. Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin.
Bio References	Inaba, K., et al. EMBO J. 29(19):3330-3343(2010) Appenzeller-Herzog, C., et al. EMBO J. 29(19):3318-3329(2010) Swiatkowska, M., et al. J. Biol. Chem. 285(39):29874-29883(2010) Chambers, J.E., et al. J. Biol. Chem. 285(38):29200-29207(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Clonality	Polyclonal
Clone/Animal Names	RB33290
Gene ID	30001
Gene Name	ERO1A (HGNC:13280)
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	ERO1L Antibody (C-term) (Cat. #AP13305b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ERO1L antibody detected the ERO1L protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	ERO1L Antibody (C-term) (Cat. #AP13305b)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ERO1L Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	NP_055399.1
Isotype	Rabbit Ig
Calculated MW	54393
Antigen Region	350-379
Antigen Source	HUMAN
Target/Specificity	This ERO1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-379 amino acids from the C-terminal region of human ERO1L.
NCBI Accession	NP_055399.1

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