Alias |
Ecto-NOX disulfide-thiol exchanger 2, APK1 antigen, Cytosolic ovarian carcinoma antigen 1, Tumor-associated hydroquinone oxidase, tNOX, Hydroquinone [NADH] oxidase, 1---, Protein disulfide-thiol oxidoreductase, 1---, ENOX2, COVA1 |
Bio Background |
The protein encoded by this gene is a growth-related cell surface protein. It was identifed because it reacts with the monoclonal antibody KI in cells, such as the ovarian carcinoma line OVCAR-3, also expressing the CAKI surface glycoprotein. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The two activities alternate with a period length of about 24 minutes. The encoded protein also displays prion-like properties. Two transcript variants encoding different isoforms have been found for this gene. |
Bio References |
Morre, D.M., et al. Rejuvenation Res 13 (2-3), 162-164 (2010) : Morre, D.M., et al. Biofactors 34(3):237-244(2009) Mao, L.C., et al. FEBS Lett. 582 (23-24), 3445-3450 (2008) : Liu, S.C., et al. Biochem. Biophys. Res. Commun. 365(4):672-677(2008) Tang, X., et al. Oncol. Res. 16(12):557-567(2007) |