SPAG8 Antibody (C-term)

Synthetic Peptide

The correlation of anti-sperm antibodies with cases of
unexplained infertility implicates a role for these antibodies in
blocking fertilization. Improved diagnosis and treatment of
immunologic infertility, as well as identification of proteins for
targeted contraception, are dependent on the identification and
characterization of relevant sperm antigens. The protein encoded by
this gene is recognized by sperm agglutinating antibodies from an
infertile woman. This protein is localized in germ cells of the
testis at all stages of spermatogenesis and is localized to the
acrosomal region of mature spermatozoa. Alternatively spliced
variants that encode different protein isoforms have been described
but the full-length sequences of only two have been determined.

Polyclonal

26206

Affinity Purified Rabbit Polyclonal Antibody (Pab)

SPAG8 Antibody (C-term) (Cat. #AP12827b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SPAG8 antibody detected the SPAG8 protein (arrow).

1:1000

Rabbit Ig

383-411

This SPAG8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-411 amino acids from the C-terminal region of human SPAG8.