SHANK2 Antibody (Center)

Q80Z38; NP_036441.2

This gene encodes a protein that is a member of the Shank
family of synaptic proteins that may function as molecular
scaffolds in the postsynaptic density (PSD). Shank proteins contain
multiple domains for protein-protein interaction, including ankyrin
repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha
motif domain, and a proline-rich region. This particular family
member contains a PDZ domain, a consensus sequence for cortactin
SH3 domain-binding peptides and a sterile alpha motif. The
alternative splicing demonstrated in Shank genes has been suggested
as a mechanism for regulating the molecular structure of Shank and
the spectrum of Shank-interacting proteins in the PSDs of adult and
developing brain. Two alternative splice variants, encoding
distinct isoforms, are reported. Additional splice variants exist
but their full-length nature has not been determined. [provided by
RefSeq].

22941

M

879-908

This SHANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 879-908 amino acids from the Central region of human SHANK2.