KLRC1 Antibody (N-term)

NP_998822.1; NP_002250.1; NP_015567.1; NP_998823.1

Natural killer (NK) cells are lymphocytes that can mediate
lysis of certain tumor cells and virus-infected cells without
previous activation. They can also regulate specific humoral and
cell-mediated immunity. The protein encoded by this gene belongs to
the killer cell lectin-like receptor family, also called NKG2
family, which is a group of transmembrane proteins preferentially
expressed in NK cells. This family of proteins is characterized by
the type II membrane orientation and the presence of a C-type
lectin domain. This protein forms a complex with another family
member, KLRD1/CD94, and has been implicated in the recognition of
the MHC class I HLA-E molecules in NK cells. The genes of NKG2
family members form a killer cell lectin-like receptor gene cluster
on chromosome 12. Four alternatively spliced transcript variants
encoding two distinct isoforms have been observed. [provided by
RefSeq].

3821

H

1-30

This KLRC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KLRC1.