HLA-DQA1 Antibody (Center)

NP_002113.2

HLA-DQA1 belongs to the HLA class II alpha chain
paralogues. The class II molecule is a heterodimer consisting of an
alpha (DQA) and a beta chain (DQB), both anchored in the membrane.
It plays a central role in the immune system by presenting peptides
derived from extracellular proteins. Class II molecules are
expressed in antigen presenting cells (APC: B Lymphocytes,
dendritic cells, macrophages). The alpha chain is approximately
33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader
peptide, exons 2 and 3 encode the two extracellular domains, and
exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Within the DQ molecule both the alpha chain and the beta chain
contain the polymorphisms specifying the peptide binding
specificities, resulting in up to four different molecules. Typing
for these polymorphisms is routinely done for bone marrow
transplantation.

3117

H

57-84

This HLA-DQA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-84 amino acids from the Central region of human HLA-DQA1.