PRDM16 Antibody (N-term)

Recombinant Protein

The reciprocal translocation t(1; 3)(p36; q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Polyclonal

63976

Purified Rabbit Polyclonal Antibody (Pab)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

1:50~100

Rabbit Ig

1-316

This PRDM16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~316 amino acids from the N-terminal region of human PRDM16.