Hersteller |
Abcepta
|
Kategorie |
|
Typ |
Antibody Primary |
Specific against |
other |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB, IHC-P |
Menge |
80 ul |
Host |
Rabbit |
ArtNr |
ABC-AP12077c-ev |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Primary Accession |
P24557 |
Antigen Type |
Synthetic Peptide |
Application |
IHC-P, WB |
Bio Background |
This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.However, this protein is considered a member of the cytochrome P450superfamily on the basis of sequence similarity rather thanfunctional similarity. This endoplasmic reticulum membrane proteincatalyzes the conversion of prostglandin H2 to thromboxane A2, apotent vasoconstrictor and inducer of platelet aggregation. Theenzyme plays a role in several pathophysiological processesincluding hemostasis, cardiovascular disease, and stroke.Alternatively spliced transcript variants encoding differentisoforms have been found for this gene. |
Bio References |
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Wang, L.H., et al. Prostaglandins Other Lipid Mediat. 68-69, 409-422 (2002) :Tazawa, R., et al. Arch. Biochem. Biophys. 334(2):349-356(1996)Baek, S.J., et al. Gene 173(2):251-256(1996)Wang, L.H., et al. Arch. Biochem. Biophys. 315(2):273-278(1994) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB17080 |
Gene ID |
6916 |
Gene Name |
TBXAS1 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
M |
Legend image 1 |
CYP5A1 Antibody (Center) (Cat. #AP12077c) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CYP5A1 antibody detected the CYP5A1 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
CYP5A1 Antibody (Center) (Cat. #AP12077c)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CYP5A1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. |
Type image 2 |
IHC-P |
Dilution image 2 |
1:10~50 |
Other Accession |
Q2PG45; Q2KIG5; NP_001052.2; NP_001124438.1 |
Predicted |
B, Pr |
Isotype |
Rabbit Ig |
Calculated MW |
60518 |
Antigen Region |
226-257 |
Antigen Source |
HUMAN |
Target/Specificity |
This CYP5A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-257 amino acids from the Central region of human CYP5A1. |
NCBI Accession |
NP_001052.2; NP_001124438.1; NP_001159726.1 |
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