ArtNr |
ABC-AP11553C |
Hersteller |
Abcepta
|
Menge |
400 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB, IF, IHC-P |
Specific against |
other |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
COX-2, COX2, PTGS2, Prostaglandin G/H synthase 2, Cyclooxygenase-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, PGH synthase 2, PGHS-2 |
Lieferbar |
|
Primary Accession |
P35354 |
Antigen Type |
Synthetic Peptide |
Application |
WB, IHC-P, IF |
Bio Background |
Prostaglandin-endoperoxide synthase (PTGS), also known ascyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are twoisozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissuedistribution. This gene encodes the inducible isozyme. It isregulated by specific stimulatory events, suggesting that it isresponsible for the prostanoid biosynthesis involved ininflammation and mitogenesis. |
Bio References |
Duggan, K.C., et al. J. Biol. Chem. 285(45):34950-34959(2010)Feher, A., et al. Am J Geriatr Psychiatry 18(11):983-987(2010)Wang, C.H., et al. Anticancer Res. 30(9):3649-3653(2010)Han, E.H., et al. J. Toxicol. Environ. Health Part A 73 (21-22), 1451-1464 (2010) :Cao, H., et al. Tohoku J. Exp. Med. 222(1):15-21(2010) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB17409 |
Gene ID |
5743 |
Gene Name |
|
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
Confocal immunofluorescent analysis of PTGS2 Antibody (Center P378) (Cat. #AP11553c) with A549 cell followed by Alexa Fluor® 489-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). |
Type image 1 |
IF |
Dilution image 1 |
1:10~50 |
Legend image 2 |
PTGS2 Antibody (Center P378) (Cat. #AP11553c) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the PTGS2 antibody detected the PTGS2 protein (arrow). |
Type image 2 |
WB |
Dilution image 2 |
1:1000 |
Legend image 3 |
Anti-PTGS2 Antibody (Center P378) at 1:2000 dilution + HACAT whole cell lysateLysates/proteins at 20 µg per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 67 kDaBlocking/Dilution buffer: 5% NFDM/TBST. |
Type image 3 |
WB |
Dilution image 3 |
1:2000 |
Legend image 4 |
PTGS2 Antibody (Center P378) (Cat. #AP11553c)immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PTGS2 Antibody (Center P378) for immunohistochemistry. Clinical relevance has not been evaluated. |
Type image 4 |
IHC-P |
Dilution image 4 |
1:10~50 |
Other Accession |
NP_000954.1 |
Isotype |
Rabbit IgG |
Calculated MW |
68996 |
Antigen Region |
363-391 |
Antigen Source |
HUMAN |
Target/Specificity |
This PTGS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 363-391 amino acids from the Central region of human PTGS2. |
NCBI Accession |
NP_000954.1 |
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