ArtNr |
ABC-AP11459b-ev |
Hersteller |
Abcepta
|
Menge |
80 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB, FC |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
CPT1C, CATL1, Carnitine O-palmitoyltransferase 1, brain isoform, CPT IC, Carnitine O-palmitoyltransferase I, brain isoform, Carnitine palmitoyltransferase 1C, CPT1-B, CPTI-B |
Lieferbar |
|
Primary Accession |
Q8TCG5 |
Antigen Type |
Synthetic Peptide |
Application |
WB, FC |
Bio Background |
The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine. |
Bio References |
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Roomets, E., et al. Invest. Ophthalmol. Vis. Sci. 49(4):1660-1664(2008)Sierra, A.Y., et al. J. Biol. Chem. 283(11):6878-6885(2008)Price, N., et al. Genomics 80(4):433-442(2002) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB19024 |
Gene ID |
126129 |
Gene Name |
CPT1C |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
CPT1C Antibody (C-term) (Cat. #AP11459b) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CPT1C antibody detected the CPT1C protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
CPT1C Antibody (C-term) (Cat. #AP11459b) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Type image 2 |
FC |
Dilution image 2 |
1:10~50 |
Other Accession |
NP_001129524.1; NP_689572.1 |
Isotype |
Rabbit Ig |
Calculated MW |
90989 |
Antigen Region |
752-782 |
Antigen Source |
HUMAN |
Target/Specificity |
This CPT1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 752-782 amino acids from the C-terminal region of human CPT1C. |
NCBI Accession |
NP_001129524.1; NP_001186681.1; NP_001186682.1; NP_689572.1 |
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