ZBTB7B Antibody

Recombinant Protein

1.Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9372-6. 2.J Biol Chem. 2000 Sep 1; 275(35):27421-38. 3.J Cell Biochem. 2009 Aug 15; 107(6):1037-45. Review.

51043

Purified Mouse Monoclonal Antibody

Figure 1: Western blot analysis using ZBTB7B mAb against HEK293 (1, 2) cell lysate.

1/500 - 1/2000

IHC

Figure 3: Immunofluorescence analysis of Hela cells using ZBTB7B mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin

1/200 - 1/1000

58027

ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.

Purified recombinant fragment of human ZBTB7B expressed in E. Coli.