ArtNr |
ABC-AO1306a |
Hersteller |
Abcepta
|
Menge |
100 ul |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
IHC, ELISA |
Clon |
1D7 |
Specific against |
other |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
NT5E, NTE, NT5, 5'-nucleotidase, Ecto-5'-nucleotidase, CD73, 5'-NT, 3.1.3.5 |
Lieferbar |
|
Primary Accession |
P21589 |
Antigen Type |
Recombinant Protein |
Application |
IHC, E |
Bio References |
1. Oncol Rep. 2007 Jun; 17(6):1341-6. 2. Neurochem Int. 2003 Dec; 43(7):621-8. |
Clonality |
Monoclonal |
Gene ID |
4907 |
Gene Name |
NT5E |
Subtitle |
Purified Mouse Monoclonal Antibody |
Reactivity |
H |
Legend image 1 |
Figure 1: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), cholangiocarcinorna (B), lymph node (C) and esophagus (D) tissues using NT5E mouse mAb with DAB staining. |
Type image 1 |
IHC |
Dilution image 1 |
1/200 - 1/1000 |
Legend image 2 |
Figure 1: Western blot analysis using FRK mouse mAb against K562 cell lysate (1). |
Type image 2 |
WB |
Dilution image 2 |
1:500~~2000 |
Isotype |
IgG1 |
Calculated MW |
63368 |
Formulation |
Ascitic fluid containing 0.03% sodium azide. |
Description |
5'-nucleotidase, ecto (NT5E), also known as CD73 (Cluster of Differentiation 73). Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. |
|
Clone: 1D7 |
Immunogen |
Purified recombinant fragment of NT5E expressed in E. Coli. |
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