FGFR4 Antibody

Recombinant Protein

1. Br J Cancer. 2006 Jun 19; 94(12):1879-86. 2. Diabetes. 2007 Oct; 56(10):2501-10.

2264

Purified Mouse Monoclonal Antibody

Figure 1: Western blot analysis using FGFR4 mouse mAb against extracellular domain
of human FGFR4 (aa22-369).

1/500 - 1/2000

IF

Figure 1: Immunohistochemical analysis of paraffin-embedded human lung squamous cell carcinoma (A), normal hepatocyte (B), colon adenocacinoma, normal stomach tissue (D), showing cytoplasmic and membrane localization using CK mouse mAb with DAB staining.

1:200~~1000

87954

FGFR4: fibroblast growth factor receptor 4. Entrez Protein NP_002002. It is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblastgrowth factor and, although its specific function is unknown, it is overexpressed in gynecologicaltumor samples, suggesting a role in breast and ovarian tumorigenesis.

Purified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line.