Vergleich

RHOA

ArtNr ABC-AM8718b-ev-50ul
Hersteller Abcepta
Menge 50 ul
Kategorie
Typ Antibody Monoclonal
Applikationen Western Blot
Specific against other
Host Mouse
Isotype IgG1 kappa
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Transforming protein RhoA, Rho cDNA clone 12, h12, RHOA, ARH12, ARHA, RHO12
Lieferbar
Primary Accession
P61586
Antigen Type
Recombinant Protein
Bio Background
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695).
Bio References
Yeramian P., et al.Nucleic Acids Res. 15:1869-1869(1987).
Fagan K.P., et al.Exp. Eye Res. 59:235-237(1994).
Puhl H.L. III, et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Kalnine N., et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Suzuki Y., et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gene ID
387
Gene Name
RHOA (HGNC:667)
Reactivity
H, M, Rat
Predicted
H, M, Rat
Calculated MW
21768
Antigen Source
HUMAN
Target/Specificity
This antibody is generated from a mouse immunized with a recombinant protein from human.

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Menge: 50 ul
Lieferbar: Out of stock
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