ArtNr |
ABC-AM8522b-ev |
Hersteller |
Abcepta
|
Menge |
50 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
Applikationen |
WB |
Specific against |
other |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
CDH1, FZR1, FYR, FZR, KIAA1242, Fizzy-related protein homolog, CDC20-like protein 1, Cdh1/Hct1 homolog, Fzr, hCDH1 |
Lieferbar |
|
Primary Accession |
Q9UM11 |
Antigen Type |
Recombinant Protein |
Application |
WB |
Bio Background |
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. |
Bio References |
Kramer E.R., et al.Curr. Biol. 8:1207-1210(1998).Kotani S., et al.Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.Sudo T., et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.Zhou Y., et al.Biochem. J. 374:349-358(2003).Nagase T., et al.DNA Res. 6:337-345(1999). |
Clonality |
monoclonal |
Clone/Animal Names |
1621CT637.76.67 |
Gene ID |
51343 |
Gene Name |
|
Subtitle |
Purified Mouse Monoclonal Antibody (Mab) |
Reactivity |
H |
Legend image 1 |
All lanes : Anti-FZR Antibody at 1:2000 dilutionLane 1: 293T/17 whole cell lysateLane 2: Hela whole cell lysateLysates/proteins at 20 µg per lane. SecondaryGoat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 55 kDaBlocking/Dilution buffer: 5% NFDM/TBST. |
Type image 1 |
WB |
Dilution image 1 |
1:2000 |
Isotype |
IgG1, k |
Calculated MW |
55179 |
Antigen Source |
HUMAN |
Target/Specificity |
This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR. |
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