ArtNr |
ABC-AM8109b-ev |
Hersteller |
Abcepta
|
Menge |
80 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
Applikationen |
WB |
Specific against |
other |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
IKBKB, IKKB, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, Nuclear factor NF-kappa-B inhibitor kinase beta, IKK-beta, IKK2, NFKBIKB, IkBKB, I-kappa-B-kinase beta, IKK-B |
Lieferbar |
|
Primary Accession |
O14920 |
Antigen Type |
Recombinant Protein |
Application |
WB |
Bio Background |
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). |
Bio References |
Downregulation of active IKK beta by Ro52-mediated autophagy. Niida M, et al. Mol Immunol, 2010 Aug. PMID 20627395.Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, et al. Pediatr Pulmonol, 2010 Jun. PMID 20503287.Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. Potter C, et al. Ann Rheum Dis, 2010 Jul. PMID 20448286.Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation. Sun W, et al. J Biol Chem, 2010 Jul 9. PMID 20448038.Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta. Yoboua F, et al. J Virol, 2010 Jul. PMID 20410276. |
Clonality |
Monoclonal |
Clone/Animal Names |
62AT992 |
Gene ID |
3551 |
Gene Name |
IKBKB |
Subtitle |
Purified Mouse Monoclonal Antibody (Mab) |
Reactivity |
H |
Legend image 1 |
The anti-IKKbeta Mab (Cat. #AM8109b) is used in Western blot to detect IKKbeta in SK-BR3 cell lysate. |
Type image 1 |
WB |
Dilution image 1 |
1:500~1000 |
Isotype |
Mouse IgG1 |
Calculated MW |
86564 |
Antigen Source |
HUMAN |
Target/Specificity |
This IKK beta antibody was raised using purified His-tagged recombinant full length human IKK beta. |
NCBI Accession |
NP_001177649.1; NP_001229707.1; NP_001547.1 |
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