Bio Background |
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms. |
Bio References |
Carter, T.C., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(2):84-93(2010) Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010) Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) : Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) : Watanabe, A., et al. Cleft Palate Craniofac. J. 43(3):310-316(2006) |