ArtNr |
ABC-ALS15663 |
Hersteller |
Abcepta
|
Menge |
50 ug |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
WB, IF, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
WIPI1, WIPI49, WD repeat domain phosphoinositide-interacting protein 1, Atg18 protein homolog, WD40 repeat protein interacting with phosphoinositides of 49 kDa, WIPI 49 kDa, WIPI-1 |
Lieferbar |
|
Primary Accession |
Q5MNZ9 |
Antigen Type |
Synthetic peptide |
Application |
WB, IHC-P, IF |
Bio Background |
Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation- induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. |
Bio References |
Proikas-Cezanne T., et al.Oncogene 23:9314-9325(2004).Ota T., et al.Nat. Genet. 36:40-45(2004).Zody M.C., et al.Nature 440:1045-1049(2006).Jeffries T.R., et al.Mol. Biol. Cell 15:2652-2663(2004).Proikas-Cezanne T., et al.FEBS Lett. 581:3396-3404(2007). |
Clonality |
Polyclonal |
Gene ID |
55062 |
Gene Name |
WIPI1 |
Subtitle |
Rabbit Polyclonal Antibody |
Reactivity |
H |
Legend image 1 |
Anti-ATG18 / WIPI1 antibody IHC staining of human small intestine. |
Type image 1 |
IHC |
Legend image 2 |
Immunofluorescence of WIPI1 in human colon tissue with WIPI1 antibody at 20 ug/ml. |
Type image 2 |
IF |
Legend image 3 |
Western blot analysis of WIPI1 in rat colon tissue lysate with WIPI1 antibody at (A) 1 and (B) 2... |
Type image 3 |
WB |
Calculated MW |
48673 |
Target/Specificity |
Human WIPI1. At least two isoforms of WIPI1 are known to exist; this antibody will detect both isoforms. |
Purification |
Immunoaffinity purified |
Concentration (mg/ml) |
1 mg/ml |
Reconstitution & Storage |
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Dilution |
IHC-P (5 µg/ml), WB (1-2 µg/ml), |
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